​Alzheimer's phase III trial Roche Graduate study

Project: ​The GRADUATE I clinical study will assess how safe and effective an investigational medication is at slowing the
progression of early (also known as ‘prodromal’) or mild Alzheimer’s disease.
Where: Newcastle and surrounds. Appointments are based at the Calvary Mater Hospital Campus, and administered by Hunter New England Health – Neuropsychiatry Service.
Contact:

Recruitment for this trial has closed. ​For more information about the trial please contact us:

  • Phone: 02 4033 5704 (Monday to Friday)
Who:

​People who:

  • Are 50 - 90 years
  • Have mild Alzheimer’s disease or memory problems that may be the early symptoms of the condition
  • Have someone they see frequently and who is willing to act as their ‘Study Partner’ throughout the duration of this study

 

Signs and symptoms of Alzheimer's disease

We all experience memory issues from time to time. But experiencing the following more and more often may be an early sign of Alzheimer’s disease:

  • Misplacing items or forgetting their names
  • Difficulty completing familiar tasks
  • Trouble following familiar routes
  • Trouble remembering recent conversations
  • Trouble remembering words and names
  • Difficulty making decisions

What this study involves

The total length of the GRADUATE I study is 3 years, including screening and follow-up. The dosing period of the study will last
for 2 years, during which half of the participants will be given the investigational medication and half will be given a placebo (a  dummy medication that contains no active ingredients). These will be given as subcutaneous (under the skin) injections at a study hospital or at home, once every 2-4 weeks. Participants will not know which group they have been assigned to. But please be assured that every participant will receive the same close monitoring throughout via regular hospital visits, regardless of their group.

Learn more

Recruitment for this trial is now closed. If you would like more information, please contact the GRADUATE I study team – they will be more than happy to help.

Do you want to talk to us?

Recruitment for this trial is now closed. If you would like to learn more about the trial please contact us via:

  • Phone 4033 5704 Monday to Friday

Project Team: HNE Mental Health – Neuropsychiatry Service – Clinical Trials  

 

​Dr Peter Schofield

Principal Investigator

​Laura Miles (main contact)

Research Project Manager

​Thomas Goodwin

Clinical Trials Coordinator

​Dr. Tanya Kerr

Clinical Neuropsychologist

​Jacqueline Richards

Clinical Neuropsychologist

 

This project has been approved by the SVH HREC and HNE RGO, Reference HREC/17/SVH/287.   Should you have concerns about your rights as a participant in this research, or you have a complaint about the manner in which the research is conducted, it may be given to the researcher, or, if an independent person is preferred, to Dr Nicole Gerrand, Professional Officer (Research Ethics), Hunter New England Human Research Ethics Committee, Hunter New England Area Health Service, Locked Bag 1, New Lambton NSW 2305 or Telephone (02) 4921 4950, email Hnehrec@hnehealth.nsw.gov.au